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eMediNexus 16 December 2022
Epidermal growth factor (EGF) boosts collagen production and sustains wound healing. However, there need to be more studies on fractional carbon dioxide (CO2) laser combined with EGF for treating acne scar.
The present study evaluated the efficacy and safety of fractional CO2 laser combined with topical EGF vs. fractional CO2 laser monotherapy for treating acne scars.
The study enrolled 23 patients with atrophic acne scars and subjected them to 3 monthly sessions of randomized split-face application of fractional CO2 laser along with topical EGF or placebo twice a day for 7 days after each laser session. It evaluated scar improvement at 1 month and 3 months post-treatment, along with wound healing response and adverse events.
The study observed:
This study shows that treatment with topical EGF after ablative fractional CO2 laser improves the clinical appearance of atrophic acne scars, and it also decreases skin pigmentation after laser treatment. Using topical EGF with post-laser ablation is safe.
Source: Ratanapokasatit Y, Sirithanabadeekul P. The efficacy and safety of epidermal growth factor combined with fractional carbon dioxide laser for acne scar treatment: a split-face trial. J Clin Aesthet Dermatol. 2022;15(7):44-8.
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